Friday, January 3, 2014

Amonia an effective compound in the treatment of seizures

Recently it has been published in a journal Nature Medicine that ammonia is effective in the treatment of genetic metabolic disorders and liver failure that often leads molecular chain reaction when the brain is exposed to ammonia. Maiken Nedergaard, M.D., D.M.Sc., co-director of the University of Rochester Medical Center (URMC) Center for Translational Neuromedicine says "Ammonia is a ubiquitous waste product of regular protein metabolism, but it can accumulate in toxic levels in individuals with metabolic disorders," In healthy people ammonia is processed in the liver, converted to urea, and flushed out from the body through urine but in people with genetic metabolic disorders, with impaired liver function due to chronic hepatitis, alcoholism, acetaminophen overdose cannot remove ammonia from their bodies quickly which leads to the concentration of ammonia in the blood, a condition called hyperammonemia. When too much ammonia enters the bloodstream it affects the central nervous system and may lead to serious consequences like tremors, seizures and, in extreme cases, can cause comas and even lead to death.

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