A strong molecular link between gut microbes and intestinal health found

According to a new research published in scientific journal Nature uncovered by the scientists of Perelman School of Medicine at the University of Pennsylvania, they have suggested the relationship between the inflammatory bowel diseases and the bacterial population in body. They have identified a molecule that somehow believed to play a big role in all this process. Through this research the team found out that HDAC3 is the basic mediator in coordinating proper intestinal uprightness and it helps to function properly in the presence of friendly bacteria. They also found out that HDAC3 and the genetic pathways also controls and are very critical in striking a healthy balance between intestinal microbes and their host. The lead author of the study, David Artis PhD, associate professor of Microbiology explains, “HDAC3 in intestinal epithelial cells regulates the relationship between commensal bacteria and mammalian intestine physiology. There's a fundamental change in the relationship between commensal bacteria and their mammalian hosts following deletion of HDAC3 in the intestine.”