Researchers have found a new biological mechanism to fight depression more effectively and rapidly

Depression affects 1 out of 10 Americans. The treatment for the same by existing drugs takes weeks and sometimes even months. Only ketamine and scopolamine shows a rapid effect for treating depression. But the side effects associated do not favour use in humans. Studies, published in Molecular Psychiatry, were conducted on biological pathways generating anti-depressant effects. Different subtypes of serotonin receptors were studied. Serotonin, a protein is known to regulate mood, memory and appetite. Studies showed that blocking serotonin 2C receptors significantly reduced depressive behaviours in mice-models, within 5 days. Serotonin 2C receptors reduce dopamine release. When blocked more dopamine released into prefrontal cortex. The studies prove effect of first biological mechanism to reduce depression. It’s also safer than current alternatives. One can get antidepressants in market which effect Serotonin 2C. But they don’t do it selectively. Researches are on to study the compounds which will help in clinical trials.