Studies show the E3 ubiquitin ligase, Itch as a major factor in stabilising the T-cells in human body

Immune system disorders in human body have been attributed to T-cells or Tregs. Their dysfunction results in disorders. A proper functioning helps suppress the immune responses of other cells. A lot of researches have been conducted in this field. Results show that even after going through differentiation, Tregs maintain their plasticity. Their regulatory profile can also be changed with some influences. Researchers have identified the Itch, and E3 ubiquitin ligase. This serves to regulate Tregs stability and influences it. The papers were published by Yun-Cai Liu and team from the La Jolla Institute for Allergy and Immunology. They further discovered that in cases where Itch was not present Tregs took on Th2 phenotype. This had many adverse effects. It led to extreme antigen induced airway inflammation. Skin lesions were common. Some other inflammations common in mice models were also found. The study gives a better understanding of allergies and asthma.