Two Drug mixture fight against glioblastomas

A new research conducted at the Harvard Medical School and Dana-Farber Cancer Institute published in Nature Medicine suggests that a combination of two oral targeted drugs can help to slow down the growth of glioblastoma brain tumors in mice. This is not all it has also helped to extend the animals survival in a big way. The scientist combined two drugs that were inhibiting over activity of two cell leading to road that drive away glioblastomas, one of the most lethal malignant brain tumors. The research team combined two drugs with a view of genetic abnormality that was found in one-third of glioblastoma. This is a mutation that disables the PTEN, a tumor- suppressor gene. The lead researcher Rosalind Segal, HMS professor of neurobiology at Dana-Farber, explains, “You have a very strong dual gas pedal" fueling the cancer's growth. These are oral drugs, taken in pill form once a day and we know they cross the blood-brain barrier and reach the tumor.”