Research has indicated that genetically acquired anti-inflammatory defect increases the chances of contacting lymphoma in children. Interleukin – 10 (IL-10) is a signaling pathway that protects the body against trauma, inflammation or infection hence its deficiency predisposes the body to inflammatory bowel diseases (VEO-IBD).
This study reported a link between VEO-IBD, IL-deficiency and tumor development. The study involved monitoring children between 5.5 and 6.5 years of age for VEO-IBD.
The findings indicated severe development of B-lymphoma cells by the children that is a rare occurrence in children blood cancer. Several children developed this conditions that led to it being regarded as unfortunate occurrence.
“when the second, third, fourth, and fifth child were diagnosed, it was clear that this was not a chance occurrence," said Alain Fischer when suggesting that lymphoma development was not by chance rather was linked to IL-10R deficiency.
Despite the determination of a link between IL-10R pathway malfunction and lymphoma development, the mechanism by which it causes cancer has not been identified. Future study should focus on this to provide solutions in cancer treatment.
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