Cancer is deadliest disease of all. This disease is always been concern for the scientist. Everyday researchers are working hard to find an effective treatment to control cancer. With same motive the researchers from Winship Cancer Institute, Emory University have found a very important control switch that is used by cancer cells. It leads to tuning down the mitochondria and also ramp up the growth when oxygen is limited. Further details of the research are published in the journal Molecular Cell.
According to this report it shows how the acetylation chemical in modified form of a protein potentially changes its function. The key metabolic enzymes push the cancer cells for rapid growth.
Jing Chen, the lead author of the research explains, “Much of the investigation of how cancer cells' altered metabolic enzymes are regulated has emphasized another chemical modification: phosphorylation. We are finding that acetylation may play an equally important role, and that metabolic enzymes' acetylation presents opportunities for anticancer drug development. ACAT1 is one of the first examples of a protein acetyltransferase in mitochondria.”