Pathogenesis cancer clues discovered in cell-conditioned media
According to a new research published in The American Journal of Pathology discovers proteins that help to explain Primary effusion lymphoma pathogenesis. The scientists have further recognized oncogenic pathways. This discovery will help in providing better and individualized treatment.
The scientists from the Istituto Nazionale dei Tumori of Milan along with the Centro di Riferimento Oncologico of Aviano, Italy, have studied the secretomes from four established PEL cell lines. Further the PEL tumor cells have been characterized by Kaposi's sarcoma-associated herpesvirus infection.
The co-researcher, Annunziata Gloghini, PhD, of the Department of Pathology of the Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy explained, “Most of the proteins we recognized in the secretome of PEL are new with respect to previous studies utilizing conventional proteomic analysis and gene expression profiling.”